Additive manufacturing in radiation oncology: a review of clinical practice, emerging trends and research opportunities

Rance Tino; Martin Leary; Adam Yeo; Elizabeth Kyriakou; Tomas Kron; Milan Brandt

doi:10.1088/2631-7990/ab70af

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Volume 2 Issue 1

Mar. 2020

Article Contents

Article Navigation > International Journal of Extreme Manufacturing > 2020 > 2(1): 012003

Tino R, Leary M, Yeo A, Kyriakou E, Kron T, Milan B. 2020. Additive manufacturing in radiation oncology: a review of clinical practice, emerging trends and research opportunities. Int. J. Extrem. Manuf. 2, 012003.

Citation:

Additive manufacturing in radiation oncology: a review of clinical practice, emerging trends and research opportunities

doi: 10.1088/2631-7990/ab70af

Rance Tino^1,2,3,
Martin Leary^1,3,
Adam Yeo²,
Elizabeth Kyriakou^1,2,
Tomas Kron^2,3,4,
Milan Brandt^{1,3
,
,}

More Information

1 RMIT Centre for Additive Manufacture, School of Engineering, RMIT University, Melbourne, Australia
2 Physical Sciences Department, Peter MacCallum Cancer Centre, Melbourne, Australia
3 ARC Industrial Transformation Training Centre in Additive Biomanufacturing, Queensland University of Technology, Brisbane, Australia
4 Centre for Medical Radiation Physics, University of Wollongong, Wollongong Australia

Publish Date: 2020-03-01

Abstract

The additive manufacturing (AM) process plays an important role in enabling cross-disciplinary research in engineering and personalised medicine. Commercially available clinical tools currently utilised in radiotherapy are typically based on traditional manufacturing processes, often leading to non-conformal geometries, time-consuming manufacturing process and highcosts. An emerging application explores the design and development of patient-specific clinical tools using AM to optimise treatment outcomes among cancer patients receiving radiation therapy. In this review, we:
• highlight the key advantages of AM in radiotherapy where rapid prototyping allows for patient-specific manufacture
• explore common clinical workflows involving radiotherapy tools such as bolus,compensators, anthropomorphic phantoms, immobilisers, and brachytherapy moulds; and
• investigate how current AM processes are exploited by researchers to achieve patient tissue-like imaging and dose attenuations.
Finally, significant AM research opportunities in this space are highlighted for their future advancements in radiotherapy for diagnostic and clinical research applications.
Keywords
- additive manufacturing,
- radiotherapy tools,
- dosimetry,
- EBRT,
- patient-specific,
- cancer treatment,
- quality assurance

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Additive manufacturing in radiation oncology: a review of clinical practice, emerging trends and research opportunities

doi: 10.1088/2631-7990/ab70af

1 RMIT Centre for Additive Manufacture, School of Engineering, RMIT University, Melbourne, Australia

2 Physical Sciences Department, Peter MacCallum Cancer Centre, Melbourne, Australia

3 ARC Industrial Transformation Training Centre in Additive Biomanufacturing, Queensland University of Technology, Brisbane, Australia

4 Centre for Medical Radiation Physics, University of Wollongong, Wollongong Australia

Publish Date: 2020-03-01

Key words:

Abstract:

The additive manufacturing (AM) process plays an important role in enabling cross-disciplinary research in engineering and personalised medicine. Commercially available clinical tools currently utilised in radiotherapy are typically based on traditional manufacturing processes, often leading to non-conformal geometries, time-consuming manufacturing process and highcosts. An emerging application explores the design and development of patient-specific clinical tools using AM to optimise treatment outcomes among cancer patients receiving radiation therapy. In this review, we:

• highlight the key advantages of AM in radiotherapy where rapid prototyping allows for patient-specific manufacture

• explore common clinical workflows involving radiotherapy tools such as bolus,compensators, anthropomorphic phantoms, immobilisers, and brachytherapy moulds; and

• investigate how current AM processes are exploited by researchers to achieve patient tissue-like imaging and dose attenuations.

Finally, significant AM research opportunities in this space are highlighted for their future advancements in radiotherapy for diagnostic and clinical research applications.